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  • Title: The preparation and characterization of ethylcellulose-walled theophylline microcapsules.
    Author: Nixon JR, Meleka MR.
    Journal: J Microencapsul; 1984; 1(1):53-64. PubMed ID: 6336515.
    Abstract:
    The use of sustained-release preparations of theophylline has become routine in the treatment of bronchial asthma. Microencapsulation provides a possible means of producing such a product. The present paper examines, by means of triangular diagrams, the phases present in the system ethylcellulose-petroleum ether-toluene. The separated cellulose was used to coat the drug theophylline. The effects of temperature, petroleum ether fraction, solvent:non-solvent ratio and rate of non-solvent addition on the size and size distribution of the microcapsules was studied.
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