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  • Title: Implications of the efficacy of thiothixene and a chlorpromazine-imipramine combination for depression in schizophrenia.
    Author: Becker RE.
    Journal: Am J Psychiatry; 1983 Feb; 140(2):208-11. PubMed ID: 6336916.
    Abstract:
    The ineffectiveness of antidepressants, and the effectiveness of neuroleptics alone, in the treatment of depressed schizophrenic patients is evidence that a pharmacologically definable depression cannot be demonstrated in schizophrenia. The author reports findings from a double-blind 1-month study of 52 anergic and depressed schizophrenic patients given thiothixene-placebo or chlorpromazine-imipramine. These findings support DSM-III, which does not diagnose intercurrent, secondary depression in the presence of schizophrenia. Consistent with most of the clinical literature, this study also supports the use of a single neuroleptic rather than neuroleptic-antidepressant combinations to treat depressive symptoms secondary to schizophrenia.
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