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  • Title: Human hybridomas from patients with malignant disease.
    Author: Sikora K, Alderson T, Ellis J, Phillips J, Watson J.
    Journal: Br J Cancer; 1983 Jan; 47(1):135-45. PubMed ID: 6336943.
    Abstract:
    Lymphocytes from 180 patients with a variety of malignant diseases were collected and fused with a human myeloma-derived line, LON-LICR-HMy2/CAM1. A total of 162 hybridomas was obtained. Only B lymphocyte markers were found on the surface of the fusion products. Flow cytometric analysis revealed a stably increased DNA content in the hybridoma cells. Some hybridoma supernatants were found to contain new Ig chains. Anti-tumour binding activity was found in 12 supernatants.
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