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  • Title: Papular polymorphic light eruption: an immunoperoxidase study using monoclonal antibodies.
    Author: Muhlbauer JE, Bhan AK, Harrist TJ, Bernhard JD, Mihm MC.
    Journal: Br J Dermatol; 1983 Feb; 108(2):153-62. PubMed ID: 6337616.
    Abstract:
    Biopsy specimens of papules taken from eight patients with polymorphic light eruption were examined by immunoperoxidase techniques employing monoclonal antibodies. In each case, most infiltrating mononuclear cells were T cells. The majority of T cells were T8-positive (cytotoxic/suppressor) in four cases and T4-positive (helper/inducer) in two. In two cases, approximately equal numbers of both T cell subsets were present. In only three cases were rare B cells identified by their reactivity with anti-IgM antibody. MI-positive mononuclear cells (macrophages) represented less than 5% of cells infiltrating the dermis. In five subjects, anti-T6 antibody stained increased numbers of dermal mononuclear cells considered to be Langerhans/indeterminate cells. The pathogenesis of papular polymorphic light eruption may involve injury to upper dermal venules mediated by T cells and Langerhans/indeterminate cells.
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