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  • Title: Inhibition of gastric acid secretion by intracerebroventricularly administered prostaglandin e2 in anaesthetized rats.
    Author: Puurunen J.
    Journal: Br J Pharmacol; 1983 Jan; 78(1):131-5. PubMed ID: 6337659.
    Abstract:
    1 The effect of intracerebroventricularly (i.c.v) administered prostaglandin E2 (PGE2) on gastric acid secretion was studied in anaesthetized rats. 2 Intracerebroventricular injections of 1 and 3 micrograms of PGE2 inhibited gastric acid secretion induced by insulin, electrical vagal stimulation and acetylcholine in a dose-dependent manner. 3 Intravenous injections of 1,3 and 10 micrograms of PGE2 had no effect on insulin-stimulated gastric acid output. 4 The results indicate that upon i.c.v. administration PGE2 inhibits gastric acid secretion by acting centrally and not peripherally after leakage from the central nervous system.
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