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  • Title: Rat myoblast fusion requires metalloendoprotease activity.
    Author: Couch CB, Strittmatter WJ.
    Journal: Cell; 1983 Jan; 32(1):257-65. PubMed ID: 6337722.
    Abstract:
    The calcium-dependent fusion of cultured rat myoblasts to multinucleate myotubes appears to require the activity of a neutral metalloendoprotease at the time of fusion. Metalloendoprotease inhibitors and synthetic dipeptide substrates prevent myoblast fusion when added to fusion-competent myoblasts with the addition of calcium. Metalloendoprotease activity has been identified and partially characterized in myoblast membranes with a fluorogenic protease substrate, and is inhibited by the same compounds that prevent fusion.
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