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  • Title: Mutagenicity of constituents of pulp and paper mill effluent in growing cells of Saccharomyces cerevisiae.
    Author: Nestmann ER, Lee EG.
    Journal: Mutat Res; 1983 Mar; 119(3):273-80. PubMed ID: 6338377.
    Abstract:
    42 compounds identified in pulp mill effluent were screened for genetic activity in growing yeast cells using strains D7 and XV185-14C without S9. In addition to 3 of these compounds that had been shown previously to be mutagenic in Salmonella. 5 more were mutagenic in strain XV185-14C. All 8 induced 2-5-fold increases in reversion frequencies over background at the trp5 locus--5 of these induced 1.5-3-fold increases at the hom3 locus and 1 induced a doubling at his1. None of the compounds induced absolute increases of gene convertants per plate in strain D7, although 3 showed increased convertant frequencies as survival decreased.
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