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  • Title: Corticotropin-releasing factor (CRF): mechanism to elevate mean arterial pressure and heart rate.
    Author: Fisher LA, Jessen G, Brown MR.
    Journal: Regul Pept; 1983 Jan; 5(2):153-61. PubMed ID: 6338566.
    Abstract:
    The efferent mechanisms by which central administration of corticotropin-releasing factor (CRF) elevates mean arterial pressure and heart rate were assessed in unanesthetized, unrestrained rats. CRF increased blood pressure and heart rate by stimulating noradrenergic sympathetic nervous outflow. CRF-induced cardiovascular changes were not dependent on anterior pituitary hormone release, adrenomedullary epinephrine secretion, the renin-angiotensin system or circulating vasopressin.
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