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  • Title: Failure of captopril to reverse the renal crisis of scleroderma.
    Author: Brown EA, Macgregor GA, Maini RN.
    Journal: Ann Rheum Dis; 1983 Feb; 42(1):52-3. PubMed ID: 6338841.
    Abstract:
    Captopril, an oral inhibitor of angiotensin converting enzyme, has recently been described as causing a dramatic reversal of the renal crisis in scleroderma in 2 patients(1). We report here 2 patients with scleroderma, hypertension, and rapidly deteriorating renal function who were given captopril. Despite good blood pressure control, captopril had no effect on renal function, both patients requiring long-term haemodialysis.
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