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  • Title: Effect of an estrogen antagonist on development of blastocysts and implantation in the hamster.
    Author: Sengupta J, Paria BC, Manchanda SK.
    Journal: J Exp Zool; 1983 Jan; 225(1):119-22. PubMed ID: 6339672.
    Abstract:
    CI 628 citrate, an estrogen antagonist, was given as a single intraluminal injection (5 micrograms) on day 3 to ovariectomized, progesterone-treated hamsters. This significantly reduced embryo cleavage rate, transformation of morula into blastocyst, and completely inhibited implantation. The effects of the drug could be reversed by estradiol-17B (1 microgram) but not estradiol-17 alpha (1 microgram) injected intraluminally with CI 628 citrate. Our finding suggests a role of estrogen present in hamster preimplantation embryo in the triggering of embryonic differentiation and implantation of the blastocyst.
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