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  • Title: [Importance of vesico-ureteral reflux in the pathogenesis of chronic pyelonephritis].
    Author: Guignard JP.
    Journal: Schweiz Med Wochenschr; 1983 Feb 12; 113(6):223-8. PubMed ID: 6340186.
    Abstract:
    Chronic pyelonephritis is secondary to urinary tract infection associated with vesico-ureteric reflux or obstructive uropathy. Pyelonephritis scarring almost always occurs in early childhood and is linked to the concomitant presence of urinary tract infection and renal papillae allowing intrarenal reflux. When bilateral, pyelonephritis scarring may lead to end-stage renal disease. Destruction of the renal parenchyma occurs over years and is often accompanied by arterial hypertension and proteinuria. Surgical correction of vesico-ureteric reflux does not prevent further renal scarring. Since sterile reflux does not appear to be harmful, it is important to diagnose vesico-ureteric reflux early and prevent urinary tract infection by administering chemoprophylaxis during the first seven years of life.
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