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  • Title: Sensitive solid phase enzyme immunoassay for factor IX antigen and classification of hemophilia B.
    Author: Takamatsu J, Kamiya T, Ogata K, Sugihara T, Koie K, Kato K.
    Journal: Haemostasis; 1983; 13(1):9-16. PubMed ID: 6341181.
    Abstract:
    A sensitive solid phase enzyme immunoassay (EIA) was developed for the measurement of factor IX antigen (IX:AG), using rabbit antihuman factor IX antiserum and beta-D-galactosidase, which enabled us to detect IX:AG as low as 10(-4)U/ml. 37 patients with severe hemophilia B have been investigated by EIA, inhibitor neutralization assay and bovine brain prothrombin time. They could be divided into four genetic variants. 25% had normal levels of IX:AG but decreased levels of factor IX clotting activity. On crossed immunoelectrophoresis of the hemophilia B+ and hemophilia BM, we could not find abnormalities in electrophoretic mobilities compared to normal subjects in the presence of 1 mM Ca++ lactate.
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