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  • Title: Characterization of a teleost gonadotropin-releasing hormone.
    Author: Sherwood N, Eiden L, Brownstein M, Spiess J, Rivier J, Vale W.
    Journal: Proc Natl Acad Sci U S A; 1983 May; 80(9):2794-8. PubMed ID: 6341999.
    Abstract:
    A peptide that is recognized by certain antibodies raised against mammalian gonadotropin-releasing hormone has been purified from extracts of salmon brains by gel filtration and high-performance liquid chromatography. The primary structure of this 10-residue peptide is less than Glu-His-Trp-Ser-Tyr-Gly-Trp-Leu-Pro-Gly-NH2. This represents a difference of two amino acids between salmon and mammalian gonadotropin-releasing hormone and demonstrates that most of the molecule has been conserved during evolution. The synthetic form of salmon gonadotropin-releasing hormone is less potent than is mammalian gonadotropin-releasing hormone on mammalian cells and is biologically active in salmon.
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