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  • Title: Failure of salicylate to reduce inhibition of human venous prostacyclin in synthesis by conventional dose aspirin.
    Author: Hanley SP, Hughes J.
    Journal: Thromb Haemost; 1983 Feb 28; 49(1):51-2. PubMed ID: 6342201.
    Abstract:
    Ex vivo venous prostacyclin synthesis was measured in 24 patients who received no medication, or a single oral dose of aspirin 300 mg, sodium salicylate, 500 mg, or a combination of sodium salicylate 500 mg followed by aspirin 300 mg 1 1/2 or 3 hr later. Aspirin alone substantially reduced PGI2 synthesis but sodium salicylate alone had no effect. Sodium salicylate administration prior to aspirin did not reverse the inhibitory effect of aspirin on PGI2 synthesis.
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