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  • Title: Certain mouse strains are deficient in a kidney brush-border metallo-endopeptidase activity.
    Author: Bond JS, Shannon JD, Beynon RJ.
    Journal: Biochem J; 1983 Jan 01; 209(1):251-5. PubMed ID: 6342606.
    Abstract:
    Preparations of microvilli from kidneys of BALB/c mice contain an alkaline metallo-endopeptidase, meprin (metallo-endopeptidase from renal tissue). Certain genealogically related inbred mice are markedly deficient in meprin activity. The meprin-deficient strains (CBA/J and C3H/HeJ) exhibit normal levels of other brush-border enzymes: alkaline phosphatase, aminopeptidase M and another proteinase, a phosphoramidon-sensitive neutral endopeptidase. Meprin deficiency cannot be attributed to a shift in pH optimum and is unlikely to be due to the presence of endogenous inhibitors.
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