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  • Title: Immunocytochemical evidence of intragranular acetylation of alpha-MSH in the melanotrophic cells of the rabbit.
    Author: Stoeckel ME, Schimchowitsch S, Garaud JC, Schmitt G, Vaudry H, Porte A.
    Journal: Cell Tissue Res; 1983; 230(3):511-5. PubMed ID: 6342803.
    Abstract:
    Melanotrophic cells of the pars intermedia of the rabbit were studied at the electron-microscopic level by means of the immuno-gold technique with the use of antisera against gamma 3-MSH and alpha-MSH. Both antibodies labelled all secretory vesicles stored in the peripheral cytoplasm, but secretory vesicles and intrasaccular condensations in the Golgi area reacting for gamma 3-MSH were not labelled with the antibody against alpha-MSH. Since this antibody appears to recognise only the acetylated form of alpha-MSH, the present observations suggest that acetylation occurs at a stage subsequent to the Golgi packaging, during maturation of the secretory vesicles. Thus, the morphological evidence supports biochemical data in favour of intragranular processing of opiomelanocortin in melanotrophic cells.
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