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  • Title: Merkel cell carcinoma: a report of three cases with neurone-specific enolase activity.
    Author: Kirkham N, Isaacson P.
    Journal: Histopathology; 1983 Mar; 7(2):251-9. PubMed ID: 6343216.
    Abstract:
    Three cases are described of a primary cutaneous neoplasm occurring in elderly patients, histological and immunohistochemical features of which support an origin from Merkel cells. Microscopically sheets of uniform small cells filled the dermis, often with a prominent trabecular pattern. Ultrastructurally the cells showed neurosecretory granules, tangles of microfilaments, scattered mitochondria and occasional intranuclear rodlets. Immunohistochemical staining for neurone-specific enolase was positive and for prekeratin was negative in each case. The definitive diagnosis of Merkel cell tumour can be made with a combination of electron microscopy and immunohistochemistry.
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