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  • Title: Met5-enkephalin-arg6-phe7 content of human and rabbit plasma.
    Author: Chou J, Tang J, Costa E.
    Journal: Life Sci; 1983 May 30; 32(22):2589-95. PubMed ID: 6343745.
    Abstract:
    Using an adsorption technique combined with high pressure liquid chromatography and a specific radioimmunoassay, the met5-enkephalin-arg6-phe7 (YGGFMRF) content was measured in human and rabbit plasma. This heptapeptide content was 0.16 +/- 0.03, 0.20 +/- 0.05 pmol/10 ml plasma, for human and rabbit plasma, respectively. The degradation of YGGFMRF injected intravenously (rabbit) or that of the opioid heptapeptide added to rabbit plasma is rapid. The biological half life (T 1/2) of 125I-YGGFMRF in rabbit plasma was about 45 seconds (in vivo) and 1 minute and 8 seconds (in vitro). The metabolic clearance rate of YGGFMRF is slower than that of met5-enkephalin. The YGGFMRF content of rabbit plasma increased following inhibition of dipeptidyl peptidase activity by an intravenous injection of captopril. The presence of met5-enkephalin-arg6-phe7 into circulation indicates that it may have some physiological role, however it is unknown whether circulating YGGFMRF originates from adrenal medulla, intermediate lobe of pituitary or some other site.
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