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  • Title: [Microbiological, kinetic and clinical study on a new cephamycin: cefotetan].
    Author: Soranzo ML, Capra E, Eandi M, Angela GC, Musso E, Bendiscioli L, Salassa B, Braida M, Lollini P, Pizzo L, Cignolo G, Spezia C, Andreoni G, Bramato C, di Nola F.
    Journal: Minerva Med; 1983 Jun 30; 74(27):1639-50. PubMed ID: 6343925.
    Abstract:
    Microbiological, kinetic and clinical studies were conducted on a new cephamycin, cephotetan. In vitro the antibiotic was found to be very effective against all strains tested. It had a particularly strong action against Gram negative bacteria too. Kinetically speaking, an intravenous bolus produced a high plasmatic concentration with a half life of about 4 hours. Elimination via the kidneys was fastest in the first 3 hours after administration (49.82%) and the slowed down. 82.76% of the dose administered was excreted within 24 hours. This antibiotics is particularly indicated in cases of urinary, respiratory and biliary infections.
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