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  • Title: Subclasses IgG1--IgG4 in 84 sera with IgG paraprotein.
    Author: Tichý M, Hrncír Z, Mracek J.
    Journal: Neoplasma; 1978; 25(1):107-10. PubMed ID: 634402.
    Abstract:
    The distribution of subclasses IgG1-4 was determined in 84 sera with IgG paraprotein. The results were as follows: IgG1--58.3%, IgG2--25%, IgG3--11.9%, IgG4--4.8%. After division into the group of IgG myelomas (n = 47) and the group of non-myeloma IgG paraproteinemias (n = 37), the following distribution was found: IgG1--55.3%, IgG2--25.5%, IgG3--12.7%, IgG4--6.5% and IgG1--62.1%, IgG2--24.3%, IgG3--10.8%, IgG4--2.7%, respectively. The distribution of light chains in the individual subclasses of IgG paraproteins was also studied. In three double IgG and IgA myeloma paraproteinemias, subclass 1 IgG paraprotein was always demonstrated.
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