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  • Title: Vitamin A, gender and ethanol interactions.
    Author: Messiha FS.
    Journal: Neurobehav Toxicol Teratol; 1983; 5(2):233-6. PubMed ID: 6346126.
    Abstract:
    The effect of short-term oral administration of Vitamin A on voluntary intake of ethanol (ET) in rats with preference to ET was studied as a function of sex and of androgen intervention. There was a statistically significant reduction in voluntary intake of ET by the Vitamin A treatment, 500 mg/kg/day for 5 days, in the female but not in the male rat. Administration of an androgen, i.e., testosterone 0.1 mg/kg/day for 5 days, exerted no effect on voluntary drinking of ET by the female rat. Coadministration of same dosage of testosterone and of Vitamin A once daily for 5 consecutive days to female rats resulted in less aversion to ET drinking compared to that obtained by Vitamin A alone. Hepatic alcohol and aldehyde-dehydrogenase were not altered by Vitamin A treatment, 500 mg/kg/day for 5 days, in female rats maintained on water ad lib. This is contrasted with induction of liver aldehyde dehydrogenase in male rats. The results suggest that aversion to ET drinking by Vitamin A is not metabolically related and is probably due to its antiestrogenic property and that testosterone partially antagonizes this effect due to its androgenic property in the female rat.
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