These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Delta5-androstenediol: kinetics of metabolism and binding to plasma proteins in normal men and women.
    Author: Bird CE, Morrow L, Fukumoto Y, Marcellus S, Clark AF.
    Journal: J Clin Endocrinol Metab; 1976 Dec; 43(6):1317-22. PubMed ID: 63469.
    Abstract:
    Using the constant fusion and single injection technique the metabolic clearance rates (mean +/- SEM) for delta5-androstene-3beta, 17beta-diol (delta5-idol) were measured for 19 normal men (1311 +/- 67 1/24 h) and 10 normal women (858 +/- 63 1/24 h). The constant infusion technique yielded values for the conversation ratios for the transformation of delta5-diol to several products: dehydroepiandrosterone (DHEA)/delta5-diol of 0.06+/-0.01 for men and 0.05 +/- 0.01 for women, of delta5-diol sulfate/delta5-diol of 0.45 +/- 0.04 for men and 0.52 +/- 0.03 for women and of DHEA sulfate/delta5-diol of 5.53 +/- 0.26 for men and 5.02 +/- 0.42 for women. The single injection technique yielded rate constants (units) and volumes of distribution (liters) for delta5-diol; Ki = 34.3 +/- 4.3 for men and 35.0 +/- 3.9 for women, K2 = 63.7 +/- 4.1 for men and 75.1 +/- 4.2 for women, V1 = 23.1 +/- 3.2 for men and 11.9 +/- 2.3 for women, V2 = 14.8 +/- 3.7 for men and 9.2 +/- 3.2 for women. The mean delta5-diol plasma concentration was 1.08 +/- 0.10 ng/ml for 12 men and 1.17 +/- 0.16 ng/ml for 9 women. (he calculated blood production rates for delta5-diol were 1357 +/- 117 mug/24 h for 12 men and 969 +/- 131 mug/24 h for 9 women. The per cent binding (equilibrium dialysis) was higher for women (94.9 +/- 0.3) than for men (93.0 +/- 0.2). Paper electrophoresis showed that significant fractions of 3H-delta5-diol migrated with both the beta-globulin and albumin fractions. Estrogen administration to two normal men increased the per cent binding of delta5-diol to plasma proteins and decreased the metabolic clearance rate towards the values found for normal women. Studies on the kinetics of delta 5-androstene-3beta,17beta-diol (delta 5-diol) metabolism and on the binding of delta 5-diol to plasma proteins in normal men and women are reported. Using the constant infusion and single injection technique the mean metabolic clearance rate for delta 5-diol was found to be 1311 1/24 hours in 19 normal men and 858 1/24 hours in 10 normal women (p less than .01). The constant infusion technique yielded values for the conversion ratios for the transformation of delta 5-diol to dehydroepiandrosteroe (DHEA)/delta 5-diol of .06 for men and .05 for women, of delta 5-diol sulfate/delta 5-diol .45 for men and .52 for women. The single injection technique yeilded rate constants (units=K) and volumes of distribution (liters) for delta 5-diol as K1=34.3 for men and 35 for women, K2-63.7 for men and 75.1 for women, V1=23.2 for men and 11.9 for women, V2-14.8 for men and 9.2 for women. mean delta 5-diol concentration was 1.08 and 1.17 ng/ml for 12 men and 9 women, respectively, while blood production rates were 1357 and 969 mcg/24 hours, respectively. Using equilibrium dialysis, the binding was 93 for men and 94.9 for women (p less than .01). Paper electrophoresis revealed significantly (p less than .01) more tritiated delta 5-diol associated with the beta-globulin area for women than for men. Estrogen administration to 2 normal men increased the percent binding of delta 5-diol to plasma proteins and decreased the metabolic clearance rate.
    [Abstract] [Full Text] [Related] [New Search]