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  • Title: [The clinical effects of a new antiviral 9-(2-hydroxyethoxymethyl) guanine (aciclovir) against herpes virus infections].
    Author: Masaoka T, Shibata H, Amaki I, Takeo H, Sakurai K, Ise T, Ohhira M, Tanaka M, Shimoyama M, Ishihara K, Shibata A, Moriyama Y, Arimori S, Nagao T, Yamada K, Ohno R, Kodera Y, Yamada H, Hirota Y, Fujiwara Y, Nakaide Y, Yoshikawa S, Yoshikawa H, Akao Y, Hattori K, Funada H, Yoshida T, Tsujino G, Sako M, Nagai K, Kanamaru A, Fujita S, Tasaka E, Hamada T, Takahashi M.
    Journal: Gan To Kagaku Ryoho; 1983 Apr; 10(4 Pt 1):944-52. PubMed ID: 6347078.
    Abstract:
    The clinical effects of a new anti-viral 9-(2-hydroxymethoxymethyl) guanine (Aciclovir) against Herpes virus infections have been investigated. The patients had malignant tumours or auto-immune disease complicated by shingles and chicken pox due to Vaicella zoster virus (VZV) (43 cases), Herpes simplex virus (HSV) (10 cases) and 9 cases which were clinically diagnosed as Herpes, though the virus was not confirmed as the causative agent. As a general principle the dosage of Aciclovir was 5 mg/kg, t. i. d. for 5 days by slow intravenous infusion. The clinically effective rate against VZV was 93%, being excellent in 42% and against HSV it was 80%, being excellent in 40% and when the results of the cases of unknown origin were included it was excellent in 40% and the cumulative effective rate was 88%. Concerning the efficacy in reduction of pain, swelling, disappearance of vesicles and new scab formation, the effect was most noticeable after the third day of treatment. Treatment given early in the disease is likely to provide better results. Concerning side effects, one of 62 patients had proteinuria and the other had a drug rash and an abnormal liver function test. It is likely that the combination of treatment and the primary disease had some influence, but the cause/effect relationship to Aciclovir treatment is not clear.
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