These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Phase II study of a new anthraquinone antineoplastic agent, mitoxantrone, in hematological malignancies].
    Author: Sampi K, Honda T, Hayashi Y, Hattori M.
    Journal: Gan To Kagaku Ryoho; 1983 Jun; 10(6):1538-9. PubMed ID: 6347083.
    Abstract:
    At Saitama Cancer Center a phase II study of mitoxantrone was carried out in 18 patients with hematological malignancy. Mitoxantrone was given at either doses of 3, 5, or 6 mg/m2 daily X 5 in 8 patients with acute leukemia, while 10 patients with NHL were given intravenously at a dose of 10, 12, or 14 mg/m2 every 3 to 4 weeks. Although remission was not obtained in patients with acute leukemia, severe hypoplastic marrow was induced in 3 patients. Of 10 patients with NHL, one achieved CR, and 4 had a PR which lasted 31 weeks, 27 weeks, 19 weeks, 12 weeks +, and 9 weeks+. These patients had previous exposure to anthracyclines. Gastrointestinal toxicity and alopecia were less frequently seen and less severe with mitoxantrone.
    [Abstract] [Full Text] [Related] [New Search]