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  • Title: [Treatment of ventriculitis caused by Staphylococcus epidermidis on equipment with the combination of fosfomycin and an aminoglycoside. Course of ventricular levels of fosfomycin].
    Author: Boulard G, Quentin C, Scontrini G, Dautheribes M, Pouguet P, Sabathie M.
    Journal: Pathol Biol (Paris); 1983 Jun; 31(6):525-7. PubMed ID: 6348662.
    Abstract:
    Five patients (4 adults and 1 child) with cerebrospinal fluid shunt infections caused by Staphylococcus epidermidis were successfully treated by fosfomycin combined with an aminoglycoside. Fosfomycin was given intravenously over 4 hours 3 times a day. The antibiotic dose was 12 g/day for adults and 200 mg/kg/day for the child. In 3 patients with an external CSF drainage system, serum and ventricular fluid samples were obtained before and after one infusion during 10 days. The serum concentrations varied greatly (48,12 +/- 31,47 and 115,07 +/- 46,5 micrograms/ml. However the drug levels in ventricular fluid were constant and similar for the 3 patients (24,48 +/- 10,28 à 27,87 +/- 8,58 micrograms/ml), well above the MICS (1 and 2 micrograms/ml).
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