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  • Title: IgA1 and IgA2 in circulating immune complexes and in renal deposits of Berger's and Schönlein-Henoch glomerulonephritis.
    Author: Coppo R, Basolo B, Mazzucco G, Bulzomì MR, Roccatello D, Messina M, Barbiano G, Martina G, Rollino C, Piccoli G.
    Journal: Proc Eur Dial Transplant Assoc; 1983; 19():648-54. PubMed ID: 6348756.
    Abstract:
    IgA subclasses in circulating immune complexes (IgA1IC), serum immunoglobulins and mesangial deposits in Berger's and Schönlein-Henoch glomerulonephritis (GN) were studied. Both IgA1IC and IgA2IC were significantly higher in Berger's and Schönlein-Henoch GN than in healthy people. In phases of clinical activity both IgAIC subclasses further increased. The IgA1/IgA2 ratio was found not to differ from controls in either groups of patients. An increase in polymeric IgA was observed in Berger's and in Schönlein-Henoch GN. Both IgA subclasses were found in mesangial deposits.
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