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  • Title: Malaria parasites adopt host cell superoxide dismutase.
    Author: Fairfield AS, Meshnick SR, Eaton JW.
    Journal: Science; 1983 Aug 19; 221(4612):764-6. PubMed ID: 6348944.
    Abstract:
    Aerobic organisms depend on superoxide dismutase to suppress the formation of dangerous species of activated oxygen. Intraerythrocytic stages of the malaria parasite exist within a highly aerobic environment and cause the generation of increased amounts of activated oxygen. Plasmodium berghei in mice was found to derive a substantial amount of superoxide dismutase activity from the host cell cytoplasm. Plasmodia isolated from mouse red cells contained mouse superoxide dismutase, whereas rat-derived parasites contained the rat enzyme. This is believed to be the first example of the acquisition of a host cell enzyme by an intracellular parasite.
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