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  • Title: The pharmacology and therapeutics of vitamin K.
    Author: Brace L.
    Journal: Am J Med Technol; 1983 Jun; 49(6):457-63. PubMed ID: 6349360.
    Abstract:
    Much has been learned in the past 10 years about the mechanism of action of coumarin anticoagulants and the role of vitamin K in the production of functional clotting factors. This paper reviews the mechanism for post-ribosomal modification of precursor proteins into functional clotting factors, the therapeutic uses of vitamin K, pharmacologic and therapeutic uses of vitamin K antagonists, and the current means of testing for vitamin K antagonism. In addition, information concerning newly discovered vitamin K-dependent proteins in other tissues and pathologic processing is discussed.
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