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Title: [Effect of long-term administration of thyroxine on the content of nucleic acids and certain indicators of phosphorus metabolism in the liver in experimental thyrotoxicosis]. Author: Makar DM, Chepovskiĭ VS. Journal: Probl Endokrinol (Mosk); 1978; 24(1):91-5. PubMed ID: 634954. Abstract: In the liver of albino rats with experimental thyrotoxicosis a study was made of nucleic acids and some indices of phosphorus metabolism: total and inorganic phosphorus, total and acid-soluble phosphorus, phosphorus of RNA, DNA and phosphoproteins. A significant elevation of the RNA and DNA content was noted 1 1/2 months from the beginning of the experiment. An increase of the concentration of nucleic acid phosphorus and a simultaneous reduction of the content of phosphorus of phosphoproteins and inorganic phosphorus was noted in the phosphorus metabolism indices under study. The content of total and acid-soluble phosphorus displayed no significant change. The data obtained indicated that, along with increased catabolism in thyrotoxicosis there occurred rather intensive synthesis, without reaching the normal level, however.[Abstract] [Full Text] [Related] [New Search]