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  • Title: [Manifestation of glucose-6-phosphate dehydrogenase deficiency caused by primaquine in malaria therapy].
    Author: Blümel P, Stögmann W.
    Journal: Padiatr Padol; 1983; 18(3):313-7. PubMed ID: 6350992.
    Abstract:
    This is a report about a 9 year old turkish boy suffering from recurrent episodes of high fever caused by Plasmodium vivax-infection (Malaria tertiana), 12 months after returning from his malarious homeland. After a 3-day course of Chloroquin, we administrated Primaquin to eliminate residual extraerythrocyte forms of Plasmodium vivax. On the 7th day of treatment acute haemolysis developped. This was caused by Glucose-6-Phosphate-Dehydrogenase-Deficiency, which could be demonstrated by a red-cell-enzyme analysis. The investigation of the patient's whole family showed the typical recessive X-linked inheritance of this enzyme-defect. Frequency and clinical manifestations of this defect are discussed.
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