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  • Title: A comparative study of atenolol and penbutolol in hypertensive patients.
    Author: Lameijer LD, Houtzagers JJ, Voermans LA.
    Journal: Eur Heart J; 1983 Jul; 4 Suppl D():53-6. PubMed ID: 6352272.
    Abstract:
    In a randomized controlled, double-blind clinical trial with 45 patients with moderate hypertension atenolol 100 mg and penbutolol 40 mg were equally effective in lowering the blood pressure. During the 6 weeks of treatment there was no change in body weight and serious side-effects were not observed, but bradycardia occurred more frequently with atenolol than with penbutolol. Withdrawal of medication during the final week of the study did not cause any adverse reaction.
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