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Title: Lysosomal enzymes and acute gastric erosions: a review. Author: Himal HS. Journal: Can J Surg; 1983 Nov; 26(6):490-1,497. PubMed ID: 6354406. Abstract: Lysosomal enzymes, acid hydrolases with acid pH optimum, are involved in cell death. Recent evidence has also indicated a role for these enzymes in the pathogenesis of acute gastric erosions. Aspirin-acid, bile-acid and bacterial peritonitis cause lysosomal instability, the release of lysosomal enzymes and acute gastric erosions. Prostaglandins such as 16,16-dimethyl prostaglandin E2 will stabilize lysosomal membranes, decrease lysosomal enzyme release and prevent acute gastric erosions.[Abstract] [Full Text] [Related] [New Search]