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  • Title: Immunohistochemistry of two glycolipid tissue antigens in human gastric carcinoma.
    Author: Wang SM, Huang TW, Hakomori S.
    Journal: Cancer; 1983 Dec 01; 52(11):2072-6. PubMed ID: 6354423.
    Abstract:
    Immunohistochemical studies of two glycolipid tissue antigens were carried out to ascertain their distribution in normal as well as cancerous gastric mucosa. A trihexose ceramide (Kiyo antigen), a precursor of ABH blood group substances, is present in epithelial cell membrane and mucin of 90% (45 of 50) of noncancerous gastric mucosa. The distribution is similar to blood group substance; 10.7% (3 of 28) of gastric carcinoma that arose in Kiyo-positive gastric mucosa exhibited complete loss of the antigen, while carcinomas from Kiyo-negative gastric mucosa remained Kiyo negative. A fucopentaose ceramide (Lex), however, is absent from noncancerous gastric mucosa but present in varying quantity in 92.9% (52 of 56) of gastric carcinomas. The emergence of Lex as a tumor cell marker in the great majority of gastric carcinomas indicates its potential application in the diagnosis and assessment of tumor loads in gastric carcinoma patients.
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