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  • Title: Anaplastic carcinoma of the thyroid with osteoclast-like giant cells.
    Author: Esmaili JH, Hafez GR, Warner TF.
    Journal: Cancer; 1983 Dec 01; 52(11):2122-8. PubMed ID: 6354425.
    Abstract:
    An unusual malignant thyroid neoplasm with a morphologic resemblance to giant cell tumor of the bone is reported in a patient who presented with a rapidly growing thyroid mass and a history of pre-existing goiter. The light and electron microscopic studies disclosed areas of differentiated follicular carcinoma with gradual transition to undifferentiated carcinoma. Pleomorphic spindle-shaped cells and giant cells were accompanied by numerous osteoclast-like multinucleated giant cells. Desmosomes and interdigitating cell surfaces were apparent in the differentiated as well as undifferentiated areas on electron microscopy. These findings support an epithelial rather than a mesenchymal origin for this neoplasm.
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