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  • Title: Red blood cell transketolase activity and the effect of thiamine supplementation in patients with chronic liver disease.
    Author: Rossouw JE, Labadarios D, Krasner N, Davis M, Williams R.
    Journal: Scand J Gastroenterol; 1978; 13(2):133-8. PubMed ID: 635453.
    Abstract:
    Biochemical evidence of thiamine deficiency was found in 58% of patients with chronic liver disease, the incidence being higher in alcoholic than in non-alcoholic patients. Daily supplementation with high doses of thiamine hydrochloride (200 mg/day) for one week restored levels of thiamine pyrophosphate (TPP), the active co-enzyme form of thiamine, to normal in all cases. Such supplementation also stimulated synthesis of the TPP dependent enzyme transketolase. Because of the essential role of TPP as a co-factor in intermediary metabolism, it is concluded that high doses of thiamine should be included in the routine nutritional management of patients with severe chronic liver disease.
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