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  • Title: A serotyping system for Clostridium welchii (C. perfringens) type A, and studies on the type-specific antigens.
    Author: Hughes JA, Turnbull PC, Stringer MF.
    Journal: J Med Microbiol; 1976 Nov; 9(4):475-85. PubMed ID: 63553.
    Abstract:
    A serotyping scheme for Clostridium welchii (C. perfringens) type A employing 57 antisera has been used to investigate the epidemiology of 153 food-poisoning outbreaks and 32 cases of gas gangrene and other clinical infections. Respectively 65% and 59% of the isolates were typable, and in 55% of the food-poisoning outbreaks the causative serotypes were established. Isolation and reporting methods that would render the typing scheme of even greater epidemiological value are described. The type-specific antigen was shown to reside in the capsule and to be lost from strains that had become rough. Development of roughness and its prevention are described. A great range of antisera and an internationally acceptable serotyping scheme is expected after integration of this set with those developed independently in America and Japan.
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