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  • Title: Tetanus toxin binding to different morphological phenotypes of cultured rat and bovine adrenal medullary cells.
    Author: Lietzke R, Unsicker K.
    Journal: Neurosci Lett; 1983 Aug 08; 38(3):233-8. PubMed ID: 6355905.
    Abstract:
    Tetanus toxin (TT) binding to cultured rat and bovine adrenal medullary cells has been investigated using indirect immunofluorescence and anti-dopamine-beta-hydroxylase (DBH) antibodies as a probe to identify catecholaminergic cells. TT binds to all rat adrenal medullary cells which display a neuronal phenotype induced by treatment with nerve growth factor and/or medium conditioned by C6 glioma cells. In contrast, 90-95% of the rounded DBH-positive cells are TT-negative, suggesting that in vitro-transdifferentiation of rat chromaffin cells alternates the expression of membrane properties. Cultured bovine chromaffin cells have no TT binding sites independent of their morphological phenotype.
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