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  • Title: Short-term treatment with sucralfate or cimetidine in gastric ulcer: preliminary results of a controlled randomized trial.
    Author: Martin F, Farley A, Gagnon M, Poitras P, Bensemana D.
    Journal: Scand J Gastroenterol Suppl; 1983; 83():37-41. PubMed ID: 6356319.
    Abstract:
    The aim of this study was to compare the healing capacities of sucralfate and cimetidine in gastric ulcer. Twenty-nine patients were randomly assigned to active sucralfate (1 g qid) and cimetidine placebo, or to cimetidine (300 mg qid) and sucralfate placebo. The patients were endoscoped before entry into the study, after 4 wk, and after 8 wk if complete healing was not found at 4 wk. Twenty-five patients completed the study. After 4 wk, 50% (6/12) of the sucralfate patients had healed in comparison to 54% (7/13) of cimetidine patients. After 8 wk, the cumulative healing rates were 75% and 77%, respectively. The results indicate that sucralfate is as effective as cimetidine in the short-term treatment of gastric ulcer.
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