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  • Title: A comparison of a combination of penbutolol and frusemide with the two compounds individually in the treatment of hypertension.
    Author: Chadha DR, Houtzagers JJ.
    Journal: Br J Clin Pharmacol; 1983 Nov; 16(5):561-4. PubMed ID: 6357258.
    Abstract:
    Forty-one patients completed a randomized, double-blind, between-group comparison of a combination of penbutolol and frusemide, with penbutolol alone, and frusemide alone in the management of mild to moderate essential hypertension. The results suggest that the combination caused a superior reduction in systolic and diastolic pressure compared with penbutolol and a superior reduction in systolic blood pressure compared with frusemide.
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