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  • Title: Chronoeffectiveness of indomethacin in four patients suffering from an evolutive osteoarthritis of hip or knee.
    Author: Job-Deslandre C, Reinberg A, Delbarre F.
    Journal: Chronobiologia; 1983; 10(3):245-54. PubMed ID: 6357659.
    Abstract:
    During a 4-week span 4 patients suffering from an evolutive osteoarthritis ingested 3 pills/day at fixed clock hours: 0800, 1200 and 2000. One of the weeks was devoted to a (placebo) control span. During the other weeks only one of the 3 ingested pills contained the daily dose of 50 mg indomethacin. This latter, when taken at 1200, had the maximum effect on self-rated pain (decrease of 60% of the 24-h mean, p less than 0.0005) and self-rated stiffness (decrease of 54% of M, p less than 0.005) as well as on mean oral temperature.
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