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  • Title: Vitamin C increases the formation of prostacyclin by aortic rings from various species and neutralizes the inhibitory effect of 15-hydroperoxy-arachidonic acid.
    Author: Beetens JR, Herman AG.
    Journal: Br J Pharmacol; 1983 Oct; 80(2):249-54. PubMed ID: 6360278.
    Abstract:
    Aortic rings from rats, rabbits and guinea-pigs produce different amounts of 6-oxo-prostaglandin F1 alpha (6-oxo-PGF1 alpha), the stable breakdown product of prostacyclin, i.e. 2760 +/- 195, 160 +/- 10 and 87 +/- 17 pg 6-oxo-PGF1 alpha per mg wet weight in 30 min. Vitamin C enhances the production of 6-oxo-PGF1 alpha by the aortic tissue of these three species, independent of their basal release. This increase was only significant if vitamin C was present in the preincubation as well as in the incubation fluid. 15-Hydroperoxy-arachidonic acid inhibits the production of 6-oxo-PGF1 alpha (IC50:6 microM) and this inhibitory effect was completely neutralized by vitamin C. The increased production of 6-oxo-PGF1 alpha is not due to an increased release of the substrate arachidonic acid. It is suggested that vitamin C enhances the formation of 6-oxo-PGF1 alpha by protecting the cyclo-oxygenase and PGI-synthase.
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