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  • Title: Microdeposits of amyloid in sclerocalcific heart valves: a histochemical and immunofluorescence study.
    Author: Goffin YA, Murdoch W, Cornwell GG, Sorenson GD.
    Journal: J Clin Pathol; 1983 Dec; 36(12):1342-9. PubMed ID: 6361072.
    Abstract:
    Amyloid associated with seven sclerotic and two normal aortic and mitral valves was studied. The sclerotic valve amyloid contained microfibrils with typical random orientation and a fibril width of 9.5-12.5 nm. The amyloid deposits demonstrated permanganate-resistant Congophilia and contained the amino acid tryptophan. Immunofluorescence studies showed P-component in amyloid deposits of 6 of 7 valves, but none of the sclerotic valves contained amyloid fibril proteins of the AL (primary), AA (secondary), AEt (medullary thyroid carcinoma) or ASc1 (senile cardiac) types. Two non-sclerotic valves, removed from a patient with systemic amyloidosis, showed permanganate-sensitive Congophilic amyloid deposits which contained amyloid fibril protein AA.
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