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  • Title: [A transurethrally transplanted model of a carcinoma in the area of the urinary bladder of the rabbit (author's transl)].
    Author: Harzmann R, Gericke D, Bichler KH, Erdmann D.
    Journal: Urologe A; 1978 Mar; 17(2):125-9. PubMed ID: 636118.
    Abstract:
    Thirty-nine rabbits were injected intratesticularly (n = 4), in the neck (n = 6), or in the submucosal area of the bladder (n = 29), with a 1-ml suspension of cells from a continuously passaged Brown-Pearce carcinoma. Actual submucosal transplantation (n = 9) caused, in addition to bladder tumors, massive metastases in the peritoneal cavity, the pleura, and the eyes. Animals receiving mucous membrane cornification prior to the submucosal infiltration (n = 15) developed exulcerated tumors in the bladder lumen and a primary bladder carcinoma like metastasis. Animals in which the tumor cell suspension was transplanted transurethrally (n = 5) likewise showed metastases in para-aortal lymph nodes and in the liver. The experiments indicate that the Brown-Pearce carcinoma, which is not indigenous to the bladder, will, with appropriate methodology, behave in a manner similar to that of a primary bladder carcinoma and can in addition be transplanted transurethrally. Tumors thus induced appear to be suitable models for studying different therapeutic approaches to bladder carcinoma.
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