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  • Title: The effects of ritodrine on prostaglandin metabolite concentrations in the blood of pregnant baboons.
    Author: Hankins GD, Strickland DM, Hauth JC, Kuehl TJ, Mitchell MD.
    Journal: Arch Gynecol; 1983; 234(1):21-6. PubMed ID: 6362573.
    Abstract:
    To investigate the relationship between beta sympathomimetic drugs and prostaglandins, we measured prostaglandin metabolites in the plasma of pregnant baboons that were given the drug ritodrine. Animals were at a mean gestation of 120 days, which is equivalent to 27 weeks in women. Ritodrine was infused i.v. at a rate of 23 micrograms/min or 80 micrograms/min for 4 h. Plasma concentrations of 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM), 11-deoxy-13,14-dihydro-15-keto-11,16-cyclo-prostaglandin E2 (PGEM-11), and 6-keto-prostaglandin-F1 alpha (6-keto-PGF1 alpha) were determined as indicators of the precursors, prostaglandin F2 alpha, prostaglandin E2, and prostacyclin (PGI2), respectively. At the 23 micrograms/min ritodrine infusion rate plasma levels of 6-keto-PGF1 alpha were decreased by 51% (+/- 15%) in the animals receiving the drug (p less than 0.005) whereas corresponding levels in control animals did not differ significantly from pre-infusion levels. At the 80 micrograms/min ritodrine infusion rate, the plasma levels of 6-keto-PGF1 alpha decreased by 66% (+/- 18%) compared with pre-infusion levels (p less than 0.001) but again the levels in control animals were not changed significantly. Plasma levels of PGFM and PGEM-11 in animals during ritodrine treatment did not differ significantly from baseline values.
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