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  • Title: Orthotopic liver transplantation in Groningen, The Netherlands (1979-1983).
    Author: Krom RA, Gips CH, Houthoff HJ, Newton D, van der Waaij D, Beelen J, Haagsma EB, Slooff MJ.
    Journal: Hepatology; 1984; 4(1 Suppl):61S-65S. PubMed ID: 6363260.
    Abstract:
    From March, 1979 to March, 1983, 26 orthotopic liver transplantations and 1 retransplantation were performed in our center. Sixteen patients are alive, 5 beyond 2 years and 1 longer than 4 years after transplantation. The actuarial 1- and 2-year survival is 60%. Factors contributing to this result are patient selection and biliary anastomosis. In cirrhotic patients, the degree of deterioration of liver function correlated with survival; in patients with hepatocellular carcinoma, extrahepatic spread of tumor was the most frequent limiting factor. Choledochocholedochostomy with a widening plasty had a low complication rate providing that the arterial blood supply was undisturbed. Until now, HLA-matching has not contributed to the result of liver transplantation, although the effect for long-term survival is still unknown. The high survival rate and excellent quality of life of long-term survivors justify liver transplantation as treatment for otherwise noncurable liver diseases.
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