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  • Title: Reduced expression of the isoleucine and valine enzymes in integration host factor mutants of Escherichia coli.
    Author: Friden P, Voelkel K, Sternglanz R, Freundlich M.
    Journal: J Mol Biol; 1984 Feb 05; 172(4):573-9. PubMed ID: 6363719.
    Abstract:
    The level of the isoleucine and valine (Ilv) enzymes specified by the ilvB and ilvGEDA operons is reduced in integration host factor mutants (himA and himD) of Escherichia coli K-12. Growth inhibition of these strains in minimal medium can be explained by the decreased amounts of one of the Ilv enzymes, acetohydroxy acid synthase I (AHASI). No growth inhibition, or reduction in AHASI activity, was found in a himA derivative of a mutant strain containing high constitutive levels of AHASI. A strong correlation was observed in himA strains between the reduced amount of the Ilv enzymes and of Ilv-specific messenger RNA. These data suggest that integration host factor may be a positive effector for transcription of the ilvB and ilvGEDA operons.
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