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  • Title: [Multicenter study of a slow-release theophylline: armophylline].
    Author: Akoun G, Battesti JP, Bignon J, Caubarrere I, Charpin J, Chicou JF, Godard P, Herman DM, Julien D, Michel FB.
    Journal: Poumon Coeur; 1983; 39(6):333-6. PubMed ID: 6364093.
    Abstract:
    In a co-operative study involving 10 centres, 95 asthmatic patients were treated with Armophylline, a new slow-release theophylline for a period of 1 to 3 months. Eighty per cent of the patients receiving the drug in doses of 11 to 15 mg/kg/day immediately had adequate blood theophylline levels (7-20 mcg/ml). There was a significant decrease in dyspnoea and number of asthmatic attacks and a significant increase in FEV1 and FEV1/VC ratio. The drug was usually well tolerated. Side-effects, such as insomnia, headache or digestive disorders were, as a rule, mild.
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