These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Clonidine promotes the accumulation of 45Ca in pancreatic beta-cell organelles.
    Author: Andersson T, Nygren P.
    Journal: Res Commun Chem Pathol Pharmacol; 1983 Dec; 42(3):369-76. PubMed ID: 6364277.
    Abstract:
    Glucose-stimulated insulin release from pancreatic islets of ob/ob-mice was inhibited by 10(-9) M of the alpha 2-adrenergic agonist clonidine. This inhibitory effect was abolished by 10(-7) M of the antagonist yohimbine. Loading the islets with 45Ca during the clonidine exposure followed by isolation of subcellular fractions under conditions known to minimize the 45Ca redistribution resulted in increased accumulation of the isotope in the mitochondrial and microsomal fractions. It is suggested that clonidine inhibits glucose-stimulated insulin release by increasing the organelle sequestration of Ca2+.
    [Abstract] [Full Text] [Related] [New Search]