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  • Title: Contrast agent induced thrombophlebitis following leg phlebography: iopamidol versus meglumine iothalamate.
    Author: Lea Thomas M, Keeling FP, Piaggio RB, Treweeke PS.
    Journal: Br J Radiol; 1984 Mar; 57(675):205-7. PubMed ID: 6365232.
    Abstract:
    A comparison was made of the incidence of venous thrombophlebitis resulting from the use of a high-osmolality contrast medium (Conray 60%, meglumine iothalamate), and a low-osmolality contrast medium (Niopam 61%, iopamidol). In 20 patients Conray was injected into one leg and Niopam into the other. The incidence of thrombophlebitis was then determined using the iodine-125 fibrinogen uptake test in a prospective, randomised, double-blind study. There was significantly less thrombophlebitis with Niopam than with Conray and it is concluded that Niopam is a safer contrast medium for phlebography.
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