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  • Title: Immunocytochemical studies on differentiation of the thyroid gland in rabbit fetuses and chick embryos.
    Author: Kameda Y.
    Journal: Histochemistry; 1984; 80(1):23-9. PubMed ID: 6365851.
    Abstract:
    The morphogenesis of the thyroid gland in rabbit fetuses and chick embryos was investigated using the PAS stain and an immunoperoxidase method with anti-19S-thyroglobulin antiserum. In rabbit fetuses, the reaction for precursor components was firstly detected in the apical portions of follicular cells, arranged in clusters but not yet forming follicles, at 16 days of gestation. Although the first primordial follicles storing colloid droplets were observed on day 18, a drastic increase of follicle formation, the true onset of thyroid function, did not occur until day 22. The colloid in primordial follicles revealed very strong immunoreactivity for 19S-thyroglobulin. The follicles gradually increased in size with age. At 25 days of gestation the cytoplasm of follicular cells was stained densely by slightly diluted 19S-thyroglobulin antiserum, whereas the colloid was stained with highly diluted antiserum; these immunoreactions of follicular cells and colloid were comparable to those of postnatal animals. In chick embryos, significant numbers of primordial follicles were observed throughout the whole thyroid parenchyma at 9 days of incubation. On day 12, the follicles stored more PAS-positive and immunoreactive colloid. At 14 days of incubation follicles with enlarged follicular lumina, having an immunoreactivity similar to mature follicles, became increasingly common.
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